General Cell Lines and Cell Cultures
Cell Applications Inc Porcine Aortic Smooth Muscle Cells Total Kit
Porcine Aortic Smooth Muscle Cells Total Kit:(P354-05) Cryopreserved (PAOSMC), 1 vial(P311-500) Porcine Smooth Muscle Cell Growth Media, 500ml(090K) Subculture Reagent Kit
Cell Applications Inc Porcine Corneal Keratocytes Cells Total Kit, adult
Porcine Corneal Keratocytes Cells Total Kit, adult(P632-05) Cryopreserved (PCK), adult 1 vial(P6111-500) Porcine Corneal Keratocytes Growth Media, 500ml(090K) Subculture Reagent Kit
Genscript Corporation CHO-K1/ mouse PD-1 Stable Cell
Programmed cell death protein 1 also known as PD-1 and CD279 (cluster of differentiation 279) is a protein that in humans is encoded by the PDCD1 gene PD-1 functioning as an immune checkpoint plays an important role in down regulating the immune system by preventing the activation of T-cells which in turn reduces autoimmunity and promotes self-tolerance The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells)
Genscript Corporation CHO-K1/Lag3 Stable Cell Line
Lymphocyte-activation gene 3 also known as LAG-3 is a protein which in humans is encoded by the LAG3 gene [1] LAG3 which was discovered in 1990[2] and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000[3] LAG-3 is a cell surface molecule with diverse biologic effects on T cell function It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders
Genscript Corporation CHO-K1/SST1/Gqi5 Stable Cell L
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner SST1 receptor is a Gi/Go-coupled GPCR which is expressed in pancreatic islets pituitary Cerebellum (Purkinje cells) frontal cortex (pyramidal cells) hippocampus (CA1-4 subfields and some granule cells of the dentate gyrus) It inhibits cAMP accumulation and stimulates tyrosine phosphatase activity it also can antiproliferation br GenScript s SST1-expressing stable cell line was made in CHO-K1/Gqi5 host cell and optimized for calcium assays
CPC Scientific H-His-Ala-Glu-Lys-His-Trp-Phe-Val-Gly-Leu-OH (trifluoroacetate salt) 1MG
ONE-LETTER SEQUENCE: HAEKHWFVGLMOLECULAR FORMULA: C59H82N16O13MOLECULAR WEIGHT:1223.40STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [198542-00-6]span>
SYNONYMS: FGF acidic I (102-111) (bovine brain)
RESEARCH AREA: Cancer
REFERENCES:
G. Gimenez-Gallego et al., Science, 230, 1385 (1985),
Eurofins Discoverx PathHunter RXFP3 Total Internalization U2OS Cell Line, 2 vials. (93-0948C3)
The PathHunter RXFP3 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of RXFP3 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged RXFP3 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the RXFP3 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS rHTR2C β-Arrestin Cell Line, 2 vials. (93-0915C3)
The PathHunter rHTR2C cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin) based activation of rHTR2C GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged rHTR2C and EA-tagged β-Arrestin-2. Activation of rHTR2C stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter VIPR1 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0739C3)
The PathHunter VIPR1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of VIPR1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged VIPR1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting VIPR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter EDG5 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0735C3)
The PathHunter EDG5 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of EDG5 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged EDG5. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting EDG5-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter DLD1 IL7R/CRLF2 Dimerization Cell Line, 2 vials. (93-1019C13)
The PathHunter IL7R/CRLF2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. TSLP) induced dimerization of IL7R/CRLF2 receptors. This product uses EFC technology. The cell line included overexpresses IL7R target protein fused to PK alongside CRLF2 target protein fused to EA. Upon ligand-induced dimerization of IL7R/CRLF2, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Eurofins Discoverx PathHunter U2OS PRLR-JAK1 Functional Assay, 2 vials. (93-0686C3)
The PathHunter PRLR-JAK1 Functional assay cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting CTKs. This cell line enables assessment of PRLR activation via detection of JAK1 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged PRLR cytokine receptor, an untagged CTK JAK1 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.